{"id":11122,"date":"2023-12-08T10:04:18","date_gmt":"2023-12-08T02:04:18","guid":{"rendered":"https:\/\/www.ztuzx.com\/?p=11122"},"modified":"2023-12-08T10:04:18","modified_gmt":"2023-12-08T02:04:18","slug":"%e5%9b%bd%e8%8d%af%e9%ad%94%e6%96%b9%ef%bc%9a2023%e5%b9%b4asco%e6%96%b0%e8%8d%af%e5%bc%80%e5%8f%91%e6%9c%ba%e4%bc%9a%e5%88%86%e6%9e%90%ef%bc%88%e9%99%84%e4%b8%8b%e8%bd%bd%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.ztuzx.com\/?p=11122","title":{"rendered":"\u56fd\u836f\u9b54\u65b9\uff1a2023\u5e74ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u5206\u6790\uff08\u9644\u4e0b\u8f7d\uff09"},"content":{"rendered":"

\u62a5\u544a\u4e0b\u8f7d\uff1a\u6dfb\u52a0199IT\u5fae\u4fe1\u516c\u4f17\u53f7\u3010i199it\u3011\uff0c\u56de\u590d\u5173\u952e\u8bcd\u30102023\u5e74ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u5206\u6790\u3011\u5373\u53ef\u4e0b\u8f7d<\/p>\n

2023\u5e74\u5373\u5c06\u5230\u6765\u4e2d\u6d82\u54c1\u724c\u7f51<\/a>\uff0c\u5bf9\u4e8e\u533b\u836f\u884c\u4e1a\u800c\u8a00\uff0c\u8fd9\u662f\u4e00\u4e2a\u503c\u5f97\u671f\u5f85\u7684\u5e74\u4efd\u3002\u5728\u8fd9\u4e00\u5e74\u7684ASCO\uff08\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff09\u4e0a\uff0c\u4e0d\u4ec5\u6709\u4f17\u591a\u521b\u65b0\u6027\u7684\u65b0\u836f\u5c06\u4eae\u76f8\uff0c\u66f4\u6709\u8bb8\u591a\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u5c06\u88ab\u63a8\u51fa\u3002\u90a3\u4e48\uff0c\u5728\u8fd9\u6837\u4e00\u4e2a\u6fc0\u52a8\u4eba\u5fc3\u7684\u65f6\u523b\uff0c\u54ea\u4e9b\u65b0\u836f\u5c06\u6210\u4e3a\u91cd\u70b9\u5173\u6ce8\u7684\u5bf9\u8c61\uff1f\u4ee5\u4e0b\u662f\u6211\u4eec\u5bf92023 ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u7684\u5206\u6790\uff1a<\/p>\n

1. PD-1\/PD-L1\u6291\u5236\u5242\u7c7b<\/p>\n

\u67d0\u533b\u836f\u7814\u7a76\u6240\u5f00\u53d1\u4e00\u79cd\u65b0\u836f__\u65b0\u836f\u5f00\u53d1\u8bba\u6587<\/p>\n

PD-1\/PD-L1\u6291\u5236\u5242\u7c7b\u4e00\u76f4\u662f\u80bf\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u70ed\u95e8\u8bdd\u9898\uff0c\u800c\u8fd9\u7c7b\u836f\u7269\u4e5f\u5c06\u662f2023 ASCO\u4e0a\u5907\u53d7\u5173\u6ce8\u7684\u5bf9\u8c61\u3002\u9664\u4e86\u76ee\u524d\u5df2\u7ecf\u4e0a\u5e02\u7684\u51e0\u79cdPD-1\/PD-L1\u6291\u5236\u5242\u4e4b\u5916\uff0c\u8fd8\u6709\u5f88\u591a\u5904\u4e8e\u7814\u53d1\u9636\u6bb5\u7684\u4ea7\u54c1\uff0c\u5982AIM2CERV\uff08\u4e0e\u764c\u7ec6\u80de\u81ea\u8eab\u8868\u8fbe\u7684\u86cb\u767d\u8d28AIM2\u76f8\u4e92\u4f5c\u7528\uff09\u3001BINTRA\uff08\u9488\u5bf9\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7684\u5355\u514b\u9686\u6297\u4f53\uff09\u3001PD-1\/CTLA-4\u53cc\u91cd\u6291\u5236\u5242\u7b49\u7b49\u3002\u5c3d\u7ba1PD-1\/PD-L1\u6291\u5236\u5242\u7c7b\u5df2\u7ecf\u5b58\u5728\u4e00\u5b9a\u7684\u5e02\u573a\u7ade\u4e89\uff0c\u4f46\u5b83\u4eec\u4ecd\u7136\u662f2023 ASCO\u4e0a\u6700\u5177\u6709\u6f5c\u529b\u7684\u65b0\u836f\u4e4b\u4e00\u3002<\/p>\n

2. CAR-T\u7ec6\u80de\u7597\u6cd5<\/p>\n

\u67d0\u533b\u836f\u7814\u7a76\u6240\u5f00\u53d1\u4e00\u79cd\u65b0\u836f__\u65b0\u836f\u5f00\u53d1\u8bba\u6587<\/p>\n

CAR-T\u7ec6\u80de\u7597\u6cd5\u662f\u4e00\u79cd\u9769\u547d\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\uff0c\u76ee\u524d\u5df2\u88abFDA\u6279\u51c6\u7528\u4e8e\u67d0\u4e9b\u8840\u6db2\u80bf\u7624\u7684\u6cbb\u7597\u3002\u968f\u7740\u8be5\u6280\u672f\u4e0d\u65ad\u53d1\u5c55\uff0c2023\u5e74\u7684ASCO\u4e0a\u5c06\u4f1a\u6709\u66f4\u591a\u7684CAR-T\u7ec6\u80de\u4ea7\u54c1\u53d1\u5e03\u3002\u4f8b\u5982\uff0cJNJ-4528\uff08\u7531\u5f3a\u6548\u6297\u4f53\u4e0eT\u7ec6\u80de\u53d7\u4f53\u7ed3\u5408\u800c\u6210\u7684CAR-T\uff09\u548cYescarta\u7684\u4e00\u79cd\u53d8\u4f53\uff08\u9488\u5bf9\u591a\u79cdB\u7ec6\u80de\u6dcb\u5df4\u7624\u7684CD19\u7279\u5f02\u6027CAR-T\uff09\u7b49\u3002\u867d\u7136CAR-T\u7ec6\u80de\u7597\u6cd5\u76ee\u524d\u4e3b\u8981\u5e94\u7528\u4e8e\u8840\u6db2\u80bf\u7624\uff0c\u4f46\u8fd9\u9879\u6280\u672f\u4e5f\u6709\u671b\u5728\u672a\u6765\u6269\u5c55\u5230\u5176\u4ed6\u7c7b\u578b\u7684\u764c\u75c7\u6cbb\u7597\u9886\u57df\u3002<\/p>\n

\u67d0\u533b\u836f\u7814\u7a76\u6240\u5f00\u53d1\u4e00\u79cd\u65b0\u836f_\u65b0\u836f\u5f00\u53d1\u8bba\u6587_<\/p>\n

3. \u65b0\u578bPARP\u6291\u5236\u5242<\/p>\n

_\u65b0\u836f\u5f00\u53d1\u8bba\u6587_\u67d0\u533b\u836f\u7814\u7a76\u6240\u5f00\u53d1\u4e00\u79cd\u65b0\u836f<\/p>\n

PARP\u6291\u5236\u5242\u662f\u4e00\u7c7b\u9488\u5bf9\u4e73\u817a\u764c\u3001\u5375\u5de2\u764c\u7b49\u56fa\u4f53\u80bf\u7624\u7684\u836f\u7269\u3002\u867d\u7136\u5df2\u7ecf\u6709\u51e0\u79cdPARP\u6291\u5236\u5242\u4e0a\u5e02\uff0c\u4f46\u8be5\u7c7b\u836f\u7269\u4ecd\u7136\u5177\u6709\u5de8\u5927\u7684\u53d1\u5c55\u6f5c\u529b\u3002\u57282023 ASCO\u4e0a\uff0c\u8bb8\u591a\u65b0\u578bPARP\u6291\u5236\u5242\u5c06\u4f1a\u53d1\u5e03\uff0c\u4f8b\u5982APG-2575\uff08\u4e00\u79cd\u53e3\u670dPARP\u6291\u5236\u5242\uff09\u3001Olaparib\u7684\u4e00\u79cd\u65b0\u578b\u5242\u578b\u7b49\u3002\u8fd9\u4e9b\u836f\u7269\u7684\u4e0a\u5e02\u5c06\u5927\u5927\u6269\u5c55PARP\u6291\u5236\u5242\u7684\u9002\u5e94\u75c7\u8303\u56f4\uff0c\u5e76\u4e3a\u80bf\u7624\u60a3\u8005\u63d0\u4f9b\u66f4\u591a\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n

4. \u65b0\u578b\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242<\/p>\n

\u9664\u4e86PD-1\/PD-L1\u6291\u5236\u5242\u7c7b\u4e4b\u5916\uff0c\u8fd8\u6709\u8bb8\u591a\u65b0\u578b\u7684\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u4e5f\u503c\u5f97\u5173\u6ce8\u3002\u4f8b\u5982TIGIT\u6291\u5236\u5242\u3001LAG-3\u6291\u5236\u5242\u3001TIM-3\u6291\u5236\u5242\u7b49\u7b49\u3002\u8fd9\u4e9b\u836f\u7269\u6709\u671b\u6253\u7834\u5f53\u524d\u514d\u75ab\u6cbb\u7597\u9886\u57df\u7684\u58c1\u5792\uff0c\u5e76\u521b\u9020\u51fa\u66f4\u597d\u7684\u6cbb\u7597\u6548<\/p>\n

\u62a5\u544a\u4e0b\u8f7d\uff1a\u6dfb\u52a0199IT\u5fae\u4fe1\u516c\u4f17\u53f7\u3010i199it\u3011\uff0c\u56de\u590d\u5173\u952e\u8bcd\u30102023\u5e74ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u5206\u6790\u3011\u5373\u53ef\u4e0b\u8f7d<\/p>\n","protected":false},"excerpt":{"rendered":"

\u62a5\u544a\u4e0b\u8f7d\uff1a\u6dfb\u52a0199IT\u5fae\u4fe1\u516c\u4f17\u53f7\u3010i199it\u3011\uff0c\u56de\u590d\u5173\u952e\u8bcd\u30102023\u5e74ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u5206\u6790\u3011\u5373\u53ef\u4e0b\u8f7d2023\u5e74\u5373\u5c06\u5230\u6765\uff0c\u5bf9\u4e8e\u533b\u836f\u884c\u4e1a\u800c\u8a00\uff0c\u8fd9\u662f\u4e00\u4e2a\u503c\u5f97\u671f\u5f85\u7684\u5e74\u4efd\u3002ASCO\u65b0\u836f\u5f00\u53d1\u673a\u4f1a\u7684\u5206\u6790\uff1a\u968f\u7740\u8be5\u6280\u672f\u4e0d\u65ad\u53d1\u5c55\uff0c2023\u5e74\u7684ASCO\u4e0a\u5c06\u4f1a\u6709\u66f4\u591a\u7684CAR-T\u7ec6\u80de\u4ea7\u54c1\u53d1\u5e03\u3002<\/p>\n","protected":false},"author":1,"featured_media":11123,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-11122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phb"],"_links":{"self":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts\/11122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11122"}],"version-history":[{"count":0,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts\/11122\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/media\/11123"}],"wp:attachment":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}