{"id":11134,"date":"2023-12-08T13:02:41","date_gmt":"2023-12-08T05:02:41","guid":{"rendered":"https:\/\/www.ztuzx.com\/?p=11134"},"modified":"2023-12-08T13:02:41","modified_gmt":"2023-12-08T05:02:41","slug":"%e3%80%8a%e7%bb%86%e8%83%9e%e7%a0%94%e7%a9%b6%e3%80%8b%ef%bc%9a%e7%99%8c%e7%bb%86%e8%83%9e%e4%b8%ba%e4%bb%80%e4%b9%88%e4%bc%9a%e8%a2%ab%e9%a5%bf%e6%ad%bb%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.ztuzx.com\/?p=11134","title":{"rendered":"\u300a\u7ec6\u80de\u7814\u7a76\u300b\uff1a\u764c\u7ec6\u80de\u4e3a\u4ec0\u4e48\u4f1a\u88ab\u201c\u997f\u6b7b\u201d\uff1f"},"content":{"rendered":"<p>\u6709\u5927\u91cf\u7684\u57fa\u7840\u7814\u7a76\u53d1\u73b0\u70ed\u91cf\u9650\u5236\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<p>\u8fd8\u6709\u4e00\u4e9b\u7814\u7a76\u5c06\u8461\u8404\u7cd6\u6c34\u5e73\u7684\u53d8\u5316\uff0c\u4e0e\u80bf\u7624\u7ec6\u80de\u4e2dp53\u86cb\u767d\u7684\u6c34\u5e73\u548c\u6d3b\u6027\u8054\u7cfb\u4e86\u8d77\u6765\u3002\u4f8b\u5982\uff0c\u8461\u8404\u7cd6\u9650\u5236\u4f1a\u5bfc\u81f4p53\u7684\u6c34\u5e73\u5347\u9ad8\u548c\u6fc0\u6d3b[2,3]\u3002<\/p>\n<p>\u4ecep53\u6fc0\u6d3b\u7684\u89d2\u5ea6\u6765\u8bf4\uff0c\u7b2c15\u548c20\u4f4d\u4e1d\u6c28\u9178\u88ab\u78f7\u9178\u5316\u4e4b\u540e\uff0c\u4f1a\u7ef4\u6301p53\u7684\u7a33\u5b9a\u6027\uff0c\u8fdb\u800c\u5bfc\u81f4\u7ec6\u80de\u5468\u671f\u505c\u6ede\uff0c\u80bf\u7624\u751f\u957f\u505c\u6b62[4]\u3002\u8fd9\u4e5f\u662f\u70ed\u91cf\u9650\u5236\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0cp53\u8fd8\u6709\u4e00\u4e2a\u66f4\u5f3a\u52b2\u7684\u6297\u764c\u529f\u80fd\uff0c\u90a3\u5c31\u662f\u8bf1\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u6fc0\u6d3b\u8fd9\u4e00\u529f\u80fd\uff0c\u9700\u8981\u78f7\u9178\u5316p53\u7684\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u3002\u7136\u800c\uff0c\u76ee\u524d\u8fd8\u4e0d\u6e05\u695a\u8461\u8404\u7cd6\u53ca\u5176\u7cd6\u9175\u89e3\u4ee3\u8c22\u4ea7\u7269\uff0c\u662f\u5426\u53ef\u4ee5\u6fc0\u6d3bp53\u7684\u8fd9\u4e00\u529f\u80fd\u3002<\/p>\n<p>\u6797\u5723\u5f69\u56e2\u961f\u9996\u5148\u8bc1\u5b9e\uff0c5mM\u4ee5\u4e0b\u6d53\u5ea6\u7684\u8461\u8404\u7cd6\u786e\u5b9e\u4f1a\u5bfc\u81f4p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u7279\u5f02\u6027\u589e\u52a0\u3002<\/p>\n<p><img src='https:\/\/www.ztuzx.com\/wp-content\/uploads\/2023\/12\/1702011755599_0.jpg' alt='_\u7ec6\u80de\u764c\u6b7b\u524d\u72b6\u51b5_\u7ec6\u80de\u764c\u4f1a\u6b7b\u4eba\u5417' \/><\/p>\n<p>\u65e2\u7136\u5982\u6b64\uff0c\u90a3\u7a76\u7adf\u662f\u8461\u8404\u7cd6\u81ea\u8eab\uff0c\u8fd8\u662f\u5176\u4ee3\u8c22\u4ea7\u7269\u5f71\u54cd\u4e86p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u5462\uff1f<\/p>\n<p>\u4ed6\u4eec\u56f4\u7ed5\u7cd6\u9175\u89e3\u901a\u8def\u5c55\u5f00\u4e86\u5730\u6bef\u5f0f\u6392\u67e5\uff0c\u6700\u540e\u786e\u5b9a\u4e0d\u662f\u8461\u8404\u7cd6\uff0c\u800c\u662f\u5176\u4ee3\u8c22\u4ea7\u72693-\u78f7\u9178\u7518\u6cb9\u9178\uff083-PGA\uff09\u5728\u8c03\u8282p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u3002<\/p>\n<p>\u7cd6\u9175\u89e3\u8def\u5f84<\/p>\n<p>\u63a5\u4e0b\u6765\u7684\u95ee\u9898\u662f\uff1a\u7a76\u7adf\u662f\u8c01\u901a\u8fc73-PGA\u611f\u77e5\u5230\u4e86\u8840\u7cd6\u7684\u53d8\u5316\uff0c\u6700\u7ec8\u8c03\u8282\u4e86p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u3002<\/p>\n<p><img src='https:\/\/www.ztuzx.com\/wp-content\/uploads\/2023\/12\/1702011755599_2.jpg' alt='\u7ec6\u80de\u764c\u4f1a\u6b7b\u4eba\u5417__\u7ec6\u80de\u764c\u6b7b\u524d\u72b6\u51b5' \/><\/p>\n<p>\u4e09\u78f7\u9178\u7518\u6cb9\u9178\u8131\u6c22\u9176\uff08PHGDH\uff09\u4ece\u514d\u75ab\u5171\u6c89\u6dc0\u5b9e\u9a8c\u4e2d\u8131\u9896\u800c\u51fa\u3002\u540e\u7eed\u5b9e\u9a8c\u8bc1\u5b9e\uff0cPHGDH\u4e0d\u4ec5\u80fd\u4e0e3-PGA\u7ed3\u5408\uff0c\u800c\u4e14\u8fd8\u80fd\u4e0ep53\u86cb\u767d\u53d1\u751f\u76f4\u63a5\u7684\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p>\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4f4e\u8461\u8404\u7cd6\u6c34\u5e73\u4f1a\u589e\u5f3aPHGDH\u4e0ep53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u800c\u52a0\u51653-PGA\u540e\uff0cPHGDH\u4e0ep53\u7684\u76f8\u4e92\u4f5c\u7528\u5c31\u4f1a\u88ab\u6291\u5236\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0c\u9700\u8981\u6ce8\u610f\u7684\u662f\uff0cPHGDH\u4f5c\u4e3a\u4e00\u79cd\u9176\uff0c\u5177\u6709\u50ac\u5316\u6d3b\u6027\uff0c\u662f\u50ac\u53163-PGA\u5408\u6210\u4e1d\u6c28\u9178\u7684\u5173\u952e\u9176\u3002\u56e0\u6b64\uff0c\u8981\u641e\u6e05\u695a\u7a76\u7adf\u662fPHGDH\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u8fd8\u662f\u5b83\u7684\u50ac\u5316\u80fd\u529b\u5728\u5f71\u54cdp53\u7684\u78f7\u9178\u5316\u3002<\/p>\n<p>\u4e8e\u662f\uff0c\u6797\u5723\u5f69\u56e2\u961f\u6784\u5efa\u4e86PHGDH\u7684\u591a\u79cd\u7a81\u53d8\u4f53\uff0c\u6709\u7684\u53ea\u5177\u6709\u7ed3\u5408\u80fd\u529b\u800c\u5931\u53bb\u50ac\u5316\u80fd\u529b\uff0c\u6709\u7684\u5219\u5b8c\u5168\u5931\u53bb\u7ed3\u5408\u80fd\u529b\u3002\u5b9e\u9a8c\u7ed3\u679c\u663e\u793a\uff0c\u4f5c\u4e3a3-PGA\u7684\u76f4\u63a5\u611f\u53d7\u5668\uff0cPHGDH\u5c06\u4f4e\u8461\u8404\u7cd6\u4fe1\u53f7\u4f20\u9012\u7ed9p53\u53ea\u9700\u8981\u5176\u7ed3\u5408\u80fd\u529b\uff0c\u800c\u4e0e\u50ac\u5316\u6d3b\u6027\u65e0\u5173\u3002<\/p>\n<p>\u8fd9\u4e00\u53d1\u73b0\u4e0e\u4e4b\u524d\u7684\u8ba4\u77e5\u76f8\u53cd\u3002\u4e4b\u524d\u6709\u7814\u7a76\u8ba4\u4e3a\uff0cPHGDH\u901a\u8fc7\u5176\u50ac\u5316\u4f5c\u7528\uff0c\u4fc3\u8fdb\u4e1d\u6c28\u9178\u7684\u5408\u6210\uff0c\u8fdb\u800c\u4fc3\u8fdb\u80bf\u7624\u7684\u751f\u957f[5,6]\u3002\u800c\u8fd9\u4e2a\u7814\u7a76\u53d1\u73b0\uff0cPHGDH\u7684\u7ed3\u5408\u529f\u80fd\u53ef\u4ee5\u901a\u8fc7p53\u8c03\u8282\u80bf\u7624\u7684\u751f\u957f\u3002<\/p>\n<p><img src='https:\/\/www.ztuzx.com\/wp-content\/uploads\/2023\/12\/1702011755599_3.jpg' alt='\u7ec6\u80de\u764c\u4f1a\u6b7b\u4eba\u5417__\u7ec6\u80de\u764c\u6b7b\u524d\u72b6\u51b5' \/><\/p>\n<p>\u968f\u7740\u8ba4\u77e5\u88ab\u5237\u65b0\u800c\u6765\u7684\uff0c\u662fPHGDH\u4e0e3-PGA\u7684\u7ed3\u5408\u7a76\u7adf\u5982\u4f55\u5f71\u54cd\u4e86p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u3002<\/p>\n<p>\u5c31\u5728\u6b64\u65f6\uff0c\u6797\u5723\u5f69\u56e2\u961f\u7684\u6ce8\u610f\u529b\u843d\u5728\u4e8620\u5e74\u524d\u7684\u4e00\u4e2a\u7814\u7a76\u4e0a\u3002<\/p>\n<p>2004\u5e74\uff0c\u4ed6\u4eec\u53d1\u73b0\uff0c\u7d2b\u5916\u7ebf\u8bf1\u5bfc\u7684DNA\u635f\u4f24\uff0c\u4f1a\u5bfc\u81f4\u4e59\u9170\u8f6c\u79fb\u9176TIP60\u548c\u6fc0\u9176HIPK2\u7ed3\u5408\u5230\u652f\u67b6\u86cb\u767dAXIN\u4e0a<a href='https:\/\/www.ztuzx.com\/'>\u4e2d\u6d82\u54c1\u724c\u7f51<\/a>\uff0c\u5b83\u4eec\u4ee8\u518d\u4e0ep53\u7ed3\u5408\uff0c\u5f62\u6210\u4e00\u4e2a\u590d\u5408\u7269\uff08AXIN-TIP60-HIPK2-p53\uff09\uff0c\u7531HIPK2\u5b8c\u6210\u5bf9p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316[7]\u3002<\/p>\n<p>\u90a3\u4e48\uff0c\u7531PHGDH\u611f\u77e5\u8461\u8404\u7cd6\u53d8\u5316\u5f15\u8d77\u7684p53\u78f7\u9178\u5316\uff0c\u4f1a\u5728\u6b64\u5904\u4e0e\u7d2b\u5916\u635f\u4f24\u5f15\u8d77\u7684p53\u78f7\u9178\u5316\u6c47\u5408\u4e48\uff1f<\/p>\n<p>\u5b9e\u9a8c\u6570\u636e\u8868\u660e\uff0c\u4e8c\u8005\u786e\u5b9e\u6c47\u5408\u4e86\u3002<\/p>\n<p>\u5728\u4f4e\u8461\u8404\u7cd6\u6c34\u5e73\u4e0b\uff0c\u7ec6\u80de\u4e2d\u7684TIP60\u3001HIPK2\u548cAXIN\u6c34\u5e73\u90fd\u4e0a\u5347\u4e86\u3002\u65e0\u8bba\u662f\u7834\u574fAXIN\u8fd8\u662fHIPK2\uff0c\u4f4e\u8461\u8404\u7cd6\u6c34\u5e73\u90fd\u4e0d\u80fd\u63d0\u9ad8p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u6c34\u5e73\u3002<\/p>\n<p>\u5728\u540e\u7eed\u7684\u7814\u7a76\u4e2d\uff0c\u6797\u5723\u5f69\u56e2\u961f\u5f88\u5feb\u5c31\u53d1\u73b0\uff0cPHGDH\u4e0e3-PGA\u7684\u7ed3\u5408\u4f1a\u963b\u6b62PHGDH\u4e0eAXIN\u7684\u7ed3\u5408\uff0c\u8fdb\u800c\u6291\u5236\u4e86AXIN-TIP60-HIPK2-p53\u7684\u5f62\u6210\uff0c\u963b\u6b62p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u88ab\u78f7\u9178\u5316\uff1b\u800c\u5728\u8461\u8404\u7cd6\u6c34\u5e73\u8f83\u4f4e\u7684\u60c5\u51b5\u4e0b\uff0c\u5219\u76f8\u53cd\u3002<\/p>\n<p>\u81f3\u6b64\uff0c\u8461\u8404\u7cd6\u6c34\u5e73\u8c03\u8282p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u7684\u78f7\u9178\u5316\u6c34\u5e73\uff0c\u8fdb\u800c\u5f71\u54cd\u5176\u8c03\u8282\u7ec6\u80de\u51cb\u4ea1\u7684\u673a\u5236\u5c31\u641e\u6e05\u695a\u4e86\u3002<\/p>\n<p><img src='https:\/\/www.ztuzx.com\/wp-content\/uploads\/2023\/12\/1702011755599_7.jpg' alt='\u7ec6\u80de\u764c\u6b7b\u524d\u72b6\u51b5__\u7ec6\u80de\u764c\u4f1a\u6b7b\u4eba\u5417' \/><\/p>\n<p>\u673a\u5236\u793a\u610f\u56fe<\/p>\n<p>\u5728\u7814\u7a76\u7684\u6700\u540e\uff0c\u6797\u5723\u5f69\u56e2\u961f\u5728\u809d\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\u9a8c\u8bc1\u4e86\u4e0a\u8ff0\u673a\u5236\u7684\u5b58\u5728\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u809d\u764c\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u4e5f\u53ef\u4ee5\u89c2\u5bdf\u52303-PGA\u4e0ep53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u78f7\u9178\u5316\u6c34\u5e73\u4e4b\u95f4\u7684\u8d1f\u76f8\u5173\u6027\u3002<\/p>\n<p>\u603b\u7684\u6765\u8bf4\uff0c\u6797\u5723\u5f69\u56e2\u961f\u7684\u8fd9\u4e2a\u7814\u7a76\u8868\u660e\uff0c\u751f\u7406\u6027\u4f4e\u8840\u7cd6\u53ef\u81ea\u4e3b\u542f\u52a8PHGDH-AXIN-TIP60-HIPK2-p53\u590d\u5408\u4f53\u7684\u5f62\u6210\uff0c\u5bfc\u81f4p53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u78f7\u9178\u5316\u6c34\u5e73\u589e\u52a0\uff0c\u8fdb\u800c\u8bf1\u53d1\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5df2\u7ecf\u6709\u7814\u7a76\u53d1\u73b0\u9ad8\u8840\u7cd6\u4e0e\u809d\u764c\u53d1\u751f\u6709\u5173[8]\uff0c\u800c\u70ed\u91cf\u9650\u5236\u996e\u98df\u53ef\u4ee5\u964d\u4f4e\u809d\u764c\u7684\u53d1\u751f\u98ce\u9669[9]\u3002\u8fd9\u4e2a\u53d1\u73b0\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4e5f\u89e3\u91ca\u4e86\u8fd9\u4e9b\u73b0\u8c61\u3002<\/p>\n<p>\u6765\u81ea\uff1a\u5947\u70b9\u7f51<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6709\u5927\u91cf\u7684\u57fa\u7840\u7814\u7a76\u53d1\u73b0\u70ed\u91cf\u9650\u5236\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002\u8fd8\u6709\u4e00\u4e9b\u7814\u7a76\u5c06\u8461\u8404\u7cd6\u6c34\u5e73\u7684\u53d8\u5316\uff0c\u4e0e\u80bf\u7624\u7ec6\u80de\u4e2dp53\u86cb\u767d\u7684\u6c34\u5e73\u548c\u6d3b\u6027\u8054\u7cfb\u4e86\u8d77\u6765\u3002\u5728\u7814\u7a76\u7684\u6700\u540e\uff0c\u6797\u5723\u5f69\u56e2\u961f\u5728\u809d\u764c\u5c0f\u9f20\u6a21\u578b\u4e2d\u9a8c\u8bc1\u4e86\u4e0a\u8ff0\u673a\u5236\u7684\u5b58\u5728\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u809d\u764c\u60a3\u8005\u7684\u80bf\u7624\u7ec4\u7ec7\u4e2d\uff0c\u4e5f\u53ef\u4ee5\u89c2\u5bdf\u52303-PGA\u4e0ep53\u7b2c46\u4f4d\u4e1d\u6c28\u9178\u78f7\u9178\u5316\u6c34\u5e73\u4e4b\u95f4\u7684\u8d1f\u76f8\u5173\u6027\u3002<\/p>\n","protected":false},"author":1,"featured_media":11135,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-11134","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-phb"],"_links":{"self":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts\/11134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11134"}],"version-history":[{"count":0,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/posts\/11134\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=\/wp\/v2\/media\/11135"}],"wp:attachment":[{"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11134"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11134"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ztuzx.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}